C-terminal peptides coassemble into A 42 oligomers and protect neurons against A 42-induced neurotoxicity

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C-terminal peptides coassemble into A 42 oligomers and protect neurons against A 42-induced neurotoxicity

Departments of *Neurology and **Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, ††Brain Research Institute, and ¶¶Molecular Biology Institute, University of California, Los Angeles, CA 90095; §Center for Polymer Studies, Department of Physics, Boston University, Boston, MA 02215; and Center for Material Science and Engineering, Material Processing Center, and ‡‡Departmen...

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Mitochondrial dysfunction plays a key role in the progression of Alzheimer's disease (AD). The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be closely related to neuronal mitochondrial dysfunction and oxidative stress. Therefore, protecting mitochondria from Aβ-induced neurotoxicity is an effective strategy for AD therapeutics. In a previous study, we fou...

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Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2008

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0807163105