Building Blood Vessels with Vascular Progenitor Cells
نویسندگان
چکیده
منابع مشابه
Vascular smooth muscle progenitor cells: building and repairing blood vessels.
Molecular pathways that control the specification, migration, and number of available smooth muscle progenitor cells play key roles in determining blood vessel size and structure, capacity for tissue repair, and progression of age-related disorders. Defects in these pathways produce malformations of developing blood vessels, depletion of smooth muscle progenitor cell pools for vessel wall maint...
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Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular de...
متن کاملFunctional tissue-engineered blood vessels from bone marrow progenitor cells.
OBJECTIVE Stem cells have significant potential for development of cell-based therapeutics for cardiovascular tissue regeneration. METHODS We developed a novel method for isolating smooth muscle cells (SMC) from ovine bone marrow using a tissue-specific promoter and fluorescence-activated cell sorting. RESULTS As compared to vascular SMC, bone marrow-derived smooth muscle progenitor cells (...
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The aim of this study was to determine the associations between the presence and extent of calcified atherosclerosis in multiple vascular beds and systolic blood pressure, diastolic blood pressure, pulse pressure, mean arterial pressure, isolated systolic hypertension, and hypertension. A total of 9510 patients (42.5% women) underwent electron beam computed tomography scanning as part of a rout...
متن کاملBuilding blood vessels in development and disease.
PURPOSE OF REVIEW This review will examine developmental angiogenesis and tumor-related changes to endothelial cells. RECENT FINDINGS Processes that govern developmental angiogenesis become dysfunctional in the tumor environment, leading to abnormal tumor endothelial cells and blood vessels. Recent findings suggest that tumor endothelial cells are permanently modified compared with normal cou...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2018
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2018.05.002