Blood Coagulation, Inflammation and Immune Reactions
نویسندگان
چکیده
منابع مشابه
Immune Reactions and Blood Coagulation
The prominence of thrombosis in the pathogenesis of the Arthns phenomenon (1, 2), the alterations in the clotting mechanism seen in experimental anaphylaxis (3), and the occurrence of "fibrinoid" in lesions generally considered to be due to hypersensit ivity suggest tha t the interaction of antigen and antibody in vivo may in some manner init iate coagulation. Experiments to be reported here in...
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Hemostatic serine proteinases-thrombin, Factor VIIa, Factor Xa, play the central role in blood coagulation and thrombosis. Activation of coagulation and generation of active proteinases is initiated by tissue factor (TF) that is expressed by cells of the innate immune system and endothelial cells after tissue damage and cell activation induced by trauma, infection, hypoxia and other cell injury...
متن کاملInflammation, innate immunity and blood coagulation.
Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response...
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The molecular links between inflammation and coagulation are unquestioned. Inflammation promotes coagulation by leading to intravascular tissue factor expression, eliciting the expression of leukocyte adhesion molecules on the intravascular cell surfaces, and down regulating the fibrinolytic and protein C anticoagulant pathways. Thrombin, in turn, can promote inflammatory responses. This create...
متن کاملNatural Coagulation Inhibitors and Inflammation.
mostasis and inflammation are closely related processes. It is recognized that the activation of hemostasis fosters, to a certain extent, inflammation and that inflammation, in turn, activates the hemostasis system. These interrelationships are best illustrated in sepsis, were microorganisms or their release products, most notably cytokines, causing inflammation, activate the hemostasis system....
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1996
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.7.268