Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
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چکیده
منابع مشابه
Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR. Experimental models of diabetes were induced with streptozotocin (STZ) treatment or Insulin2 gene mutation (Akita) in mice. Protein expression and localization wer...
متن کاملDiabetic retinopathy and vascular endothelial growth factor
| June 2013 | 536 paradox. According to this hypothesis, it seems that during the short period, arteriogenesis is reduced in diabetes mellitus due to VEGF resistance, however, in long‐period, angiogenesis increases in spite of VEGF resistance the results of high and continuous stimulation of VEGF.[5] Increase in arteriogenesis is associated with collateral vessel formation, while, increase in a...
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The study included 20 patients with diabetes mellitus type I (DM I) and 16 with type II (DM II) suffering from prolipherative diabetic retinopathy (PDR) for which they underwent vitrectomy. The quantity of VEGF and its receptors in the vitreous of investigated patients were measured by immunoassay and results compared between patients with DM I and II. The mean levels in the vitreous were signi...
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Background and Objective: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and R2) are major regulators of angiogenesis. This study was designed to assess serum levels of VEGF and VEGF-R1 and their prognostic significance in newly diagnosed childhood acute leukemia. Materials and Methods: For this purpose, VEGF and VEGF-R1 were determined using enzyme linked immuno-sorba...
متن کاملVascular endothelial growth factor and vascular permeability changes in human diabetic retinopathy.
PURPOSE The authors used histochemical analysis to determine whether increased vascular endothelial growth factor (VEGF) immunoreactivity in diabetic retinal vessels is related to increased vascular permeability, as indicated by human serum albumin (HSA) immunostaining, or to presumed retinal hypoxia as demonstrated by decreased vascularity. A correlation between VEGF and HSA in cryosections wi...
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ژورنال
عنوان ژورنال: Journal of Ophthalmology
سال: 2015
ISSN: 2090-004X,2090-0058
DOI: 10.1155/2015/605946