Biological function of activation-induced cytidine deaminase (AID)
نویسندگان
چکیده
منابع مشابه
Activation-induced cytidine deaminase (AID)
Activation-induced cytidine deaminase (AID) plays an essential role in the generation of a highly competent repertoire of antibodies by participating in class switch recombination (CSR) and somatic hypermutation (SHM). After B cell stimulation by antigens, AID initiates SHM and CSR by deamination of cytidine to uridine in the variable and constant regions of Ig genes. An adverse effect of AID’s...
متن کاملEvolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.
Following activation of mammalian B cells, class switch recombination (CSR) and somatic hypermutation (SHM) of the Ig heavy chain (IgH) gene can improve the functions of the expressed antibodies. Activation-induced cytidine deaminase (AID) is the only known B cell-specific protein required for inducing CSR and SHM in mammals. Lower vertebrates have an AID homologue, and there is some evidence o...
متن کاملInvolvement of activation-induced cytidine deaminase (AID) in the development of colitis-associated colorectal cancers
No conflicts of interest exist. Chronic inflammatory bowel disease is an important etiologic factor in the development of colorectal cancer. The mechanism underlying the development of colorectal cancers through chronic inflammation, however, is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutation in the immunoglobulin gene. We ...
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Genetic abnormalities such as nucleotide alterations and chromosomal disorders that accumulate in various tumor-related genes have an important role in cancer development. The precise mechanism of the acquisition of genetic aberrations, however, remains unclear. Activation-induced cytidine deaminase (AID), a nucleotide editing enzyme, is essential for the diversification of antibody production....
متن کاملInduction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein
The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci. Using chromosomally integrated fluorescence reporter transgenes, we demonstrate a new recombinogenic activity of AID leading to intra- and intergenic deletions via homologous recombination of sequence ...
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ژورنال
عنوان ژورنال: Biomedical Journal
سال: 2014
ISSN: 2319-4170
DOI: 10.4103/2319-4170.128734