Atrial Glutathione Content, Calcium Current, and Contractility
نویسندگان
چکیده
منابع مشابه
Surgical Treatment of Concomitant Atrial Fibrillation: Focus onto Atrial Contractility
BACKGROUND Maze procedure aims at restoring sinus rhythm (SR) and atrial contractility (AC). This study evaluated multiple aspects of AC recovery and their relationship with SR regain after ablation. METHODS 122 mitral and fibrillating patients underwent radiofrequency Maze. Rhythm check and echocardiographic control of biatrial contractility were performed at 3, 6, 12, and 24 months postoper...
متن کاملChronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.
BACKGROUND Atrial fibrillation is characterized by progressive atrial structural and electrical changes (atrial remodeling) that favor arrhythmia recurrence and maintenance. Reduction of L-type Ca(2+) current (I(Ca,L)) density is a hallmark of the electrical remodeling. Alterations in atrial microRNAs could contribute to the protein changes underlying atrial fibrillation-induced atrial electric...
متن کاملAVE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat.
BACKGROUND The loss of atrial contractile function after cardioversion of atrial fibrillation (AF) contributes to the thromboembolic risk associated with AF. The newly developed blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)) AVE0118 prolongs atrial action potential duration and might therefore enhance atrial contractility. We compared the abil...
متن کاملEffects of Acetaminophen on Left Atrial Contractility.
BACKGROUND It has been observed that acetaminophen shows cardioprotective efficacy in mammals. In this study, we investigated the electromechanical effects of acetaminophen on the left atrium (LA). METHODS Conventional microelectrodes were used to record the action potentials (AP) in rabbit LA preparations. The action potential duration (APD) at repolarization levels of 90%, 50% and 20% of th...
متن کاملGlutathione Content of Normal Animals
Previous contributions from this laboratory have clearly demonstrated that glutathione is specifically concerned in the chemical defense of the body against the action of certain poisons (arsenic, copper, gold, cyanide, methylene blue, etc.). We put forward the theory that the toxic action of these substances is due to a primary disturbance of the cellular oxidation-reduction processes, resulti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m704893200