Assessment of SNP-SNP interactions by using square contingency table analysis
نویسندگان
چکیده
منابع مشابه
Multiple testing for SNP-SNP interactions.
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction patterns given as expressions linked by logical operators. Methods for multiple testing in high-dimensional settings can be applied when many SNPs are considered simultaneously. However, another less we...
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Interactions of single nucleotide polymorphisms (SNPs) are assumed to be responsible for complex diseases such as sporadic breast cancer. Important goals of studies concerned with such genetic data are thus to identify combinations of SNPs that lead to a higher risk of developing a disease and to measure the importance of these interactions. There are many approaches based on classification met...
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SNPsyn (http://snpsyn.biolab.si) is an interactive software tool for the discovery of synergistic pairs of single nucleotide polymorphisms (SNPs) from large genome-wide case-control association studies (GWAS) data on complex diseases. Synergy among SNPs is estimated using an information-theoretic approach called interaction analysis. SNPsyn is both a stand-alone C++/Flash application and a web ...
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It is being increasingly accepted that traditional statistical Single Nucleotide Polymorphism (SNP) analysis of Genome-Wide Association Studies (GWAS) reveals just a small part of the heritability in complex diseases. Study of SNPs interactions identify additional SNPs that contribute to disease but that do not reach genome-wide significance or exhibit only epistatic effects. We have introduced...
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Prostate cancer (PCa) is one of the most significant male health concerns worldwide. Single nucleotide polymorphisms (SNPs) are becoming increasingly strong candidate biomarkers for identifying susceptibility to PCa. We identified a number of SNPs reported in genome-wide association analyses (GWAS) as risk factors for aggressive PCa in various European populations, and then defined SNP-SNP inte...
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ژورنال
عنوان ژورنال: Anais da Academia Brasileira de Ciências
سال: 2020
ISSN: 1678-2690,0001-3765
DOI: 10.1590/0001-3765202020190465