Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease
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چکیده
منابع مشابه
Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease
Increased hyperphosphorylated tau and the formation of intracellular neurofibrillary tangles are associated with the loss of neurons and cognitive decline in Alzheimer's disease, and related neurodegenerative conditions. We applied two diffusion models, diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), to in vivo diffusion magnetic resonance images (...
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This paper introduces neurite orientation dispersion and density imaging (NODDI), a practical diffusion MRI technique for estimating the microstructural complexity of dendrites and axons in vivo on clinical MRI scanners. Such indices of neurites relate more directly to and provide more specific markers of brain tissue microstructure than standard indices from diffusion tensor imaging, such as f...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2016
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2015.10.043