Antitumor Activity of New Antitumor Substance, Polyoxomolybdate, against Several human Cancers in Athymic Nude Mice.
نویسندگان
چکیده
منابع مشابه
Antitumor efficacy of N1,N11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice.
The spermine analogue N1,N11-diethylnorspermine (DENSPM) has been shown to induce the polyamine-acetylating enzyme spermidine/spermine N1-acetyltransferase, disrupt polyamine pool homeostasis, and inhibit tumor growth. DENSPM is currently being developed as an anti-neoplastic agent and is about to enter Phase II clinical trials. In this report, the antitumor efficacy of DENSPM was evaluated aga...
متن کاملMonoclonal antibody homodimers: enhanced antitumor activity in nude mice.
The potential for enhancing antibody potency by increasing avidity was investigated using monoclonal IgG homodimers. Chemically linked dimers were made from a human-murine chimeric monoclonal IgG (ChiBR96) which strongly binds to a variety of breast, lung, ovary, and colon carcinomas. This monoclonal antibody is capable of killing tumor cells directly without complement or effector cells in add...
متن کاملAntitumor activities of seventeen alkylating agents against human mammary carcinoma (MS-1) in nude mice.
The antitumor activities of seventeen antitumor alkylating agents have been studied in the xenograft of human mammary carcinoma transplanted in nude mice (MX-I). The drugs employed in this study were; cyclophosphamide. ifosfamide. 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCN U). 1-(2-ehloroethyl)3-(4-methylcyclohexyl)-I-nitrosourea (me-CCN U). 2-[3-(2-ehloroethyl)-3-nitrosoureido]-2-deoxyD...
متن کاملAntitumor activity of cobrotoxin in human lung adenocarcinoma A549 cells and following transplantation in nude mice
The aim of the present study was to investigate cobra neurotoxin (cobrotoxin) activity in A549 cell lines transplanted into nude mice, and to explore its molecular mechanism. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method was used to detect the growth inhibition rate of cobrotoxin in human lung A549 adenocarcinoma cells and HFL1 lung fibroblasts. Cell colony forma...
متن کاملAntitumor Activity and In Vivo Antioxidant Status of Mucuna Pruriens (Fabaceae) Seeds against Ehrlich Ascites Carcinoma in Swiss Albino Mice
The aim of the present study is to evaluate the antitumor effect and antioxidant role of Mucuna pruriens (Family: Fabaceae) against EAC bearing Swiss albino mice. The effect of methanol extract of Mucuna pruriens (MEMP) on tumor growth and hosts survival time was studied by the following parameters: tu-mor volume, packed cell volume, viable and non-viable cell count and life span of the host. M...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1992
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.168.421