Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI)

A novel antimicrobial peptide, GAPI, has been developed recently by grafting gallic acid (GA) to polyphemusin I (PI). The objective of this study was investigate the antibacterial effects GAPI on common oral pathogens. This laboratory used minimum inhibitory concentrations and bactericidal assess properties against Transmission electron microscopy examine bacterial morphology both before after treatment. results showed that concentration ranged from 20 μM (Lactobacillus rhamnosus) 320 (Porphyromonas gingivalis), whereas 80 acidophilus) 640 (Actinomyces naeslundii, Enterococcus faecalis, Porphyromonas gingivalis). abnormal curvature cell membranes, irregular shapes, leakage cytoplasmic content, disruption membranes walls. In conclusion, peptide is pathogens, with potential be manage infections.