Antibacterial Drug Shortages From 2001 to 2013: Implications for Clinical Practice

Antibacterial drug shortages from 2001 to 2013: implications for clinical practice.

BACKGROUND Previous studies have described drug shortages; however, there has been no comprehensive evaluation focusing on US antibacterial shortages. METHODS Drug shortage data from the University of Utah Drug Information Service database were analyzed, with a focus on antibacterial agents from 2001 to 2013. We used descriptive statistics to describe trends in drug shortages, analyze drug cl...

Drug Shortages Delay Cancer Clinical Trials.

T he mean survival time for people older than 60 years with acute myeloid leukemia (AmL) is about 7 months. only 15% survive 5 years or longer, and that percentage hasn't changed in decades. the poor prognosis for these patients is due in part to the fact that many cannot tolerate the toxic chemotherapy used as first-line treatment, a combination of cytarabine and daunorubicin. Both are generic...

Drug transporters and imatinib treatment: implications for clinical practice.

Imatinib mesylate is approved for the treatment of chronic myeloid leukemia (CML) and advanced gastrointestinal stromal tumors (GIST). Unfortunately, in the course of treatment, disease progression occurs in the majority of patients with GIST. Lowered plasma trough levels of imatinib over time potentially cause disease progression, a phenomenon known as "acquired pharmacokinetic drug resistance...

Australian alcohol policy 2001–2013 and implications for public health

BACKGROUND Despite a complex and multi-faceted alcohol policy environment in Australia, there are few comprehensive reviews of national and state alcohol policies that assess their effectiveness and research support. In mapping the Australian alcohol policy domain and evaluating policy interventions in each of the core policy areas, this article provides a useful resource for researchers. The i...

Professional Practice Committee for the 2013 Clinical Practice Recommendations