Anti-dihydropyridine Antibodies Exhibit [3H]Nitrendipine Binding Properties Similar to the Membrane Receptor for the 1,4-Dihydropyridine Ca2+ Channel Antagonists
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منابع مشابه
Anti-dihydropyridine Antibodies Exhibit [H]Nitrendipine Binding Properties Similar to the Membrane Receptor for the 1,4-Dihydropyridine Ca Channel Antagonists
The [H]nitrendipine binding properties of antidihydropyridine antibodies were characterized and compared with the known [H]nitrendipine binding properties of the membrane receptor for the 1,4-dihydropyridine Ca channel antagonists. Immunization of rabbits with dihydropyridine-protein conjugates resulted in the production of antibodies with high affinity and specificity for the 1,4-dihydropyridi...
متن کاملHigh-affinity antibodies to the 1,4-dihydropyridine Ca2+-channel blockers.
Antibodies with high affinity and specificity for the 1,4-dihydropyridine Ca2+-channel blockers have been produced in rabbits by immunization with dihydropyridine-protein conjugates. Anti-dihydropyridine antibodies were found to specifically bind [3H]nitrendipine, [3H]-nimodipine, [3H]nisoldipine, and [3H]PN 200-110 (all 1,4-dihydropyridine Ca2+-channel blockers) with high affinity, while [3H]v...
متن کاملPHARMAC responds to Stewart Mann on dihydropyridine calcium channel antagonists.
PHARMAC’s legislative objective is “to secure for eligible people in need of pharmaceuticals, the best health outcomes that are reasonably achievable from pharmaceutical treatment and from within the amount of funding provided.” Two of the ways in which PHARMAC achieves this is by reference pricing and by negotiating sole supply contracts with pharmaceutical suppliers. When managed appropriatel...
متن کاملAffinity purification of antibodies specific for 1,4-dihydropyridine Ca2+ channel blockers.
High-affinity antibodies specific for the 1,4-dihydropyridine Ca2+ channel blockers have been produced in sheep and affinity purified using a dihydropyridine-Sepharose affinity column. Dihydropyridine-Sepharose affinity matrix was synthesized by reaction of aminohexyl-Sepharose with an affinity analogue of nifedipine, dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-isothiocyanatophenyl)-3,5-pyridine-dic...
متن کاملPotent inhibition of native TREK-1 K+ channels by selected dihydropyridine Ca2+ channel antagonists.
Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 background K+ channels that set the resting membrane potential. Whole-cell and single-channel patch-clamp recording were used to compare five Ca2+ channel antagonists with respect to their potency as inhibitors of native bTREK-1 K+ channels. The dihydropyridine (DHP) Ca2+ channel antagonists amlodipine and niguldipine potently and spec...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 1987
ISSN: 0160-2446
DOI: 10.1097/00005344-198700094-00019