Animal models for highly pathogenic emerging viruses

Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses.

A diverse group of highly pathogenic RNA viruses cause a severe multisystemic illness in humans commonly referred to as viral hemorrhagic fever (VHF). Although they can vary widely in clinical presentation, all VHFs share certain features that include intense fever, malaise, bleeding and shock. Effective antiviral therapies for most of the VHFs are lacking. Complicating development of intervent...

Emerging and re-emerging animal viruses. Foreword

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau...

Evolution, safety, and highly pathogenic influenza viruses.

Experience with influenza has shown that predictions of virus phenotype or fitness from nucleotide sequence are imperfect and that predicting the timing and course of evolution is extremely difficult. Such uncertainty means that the risk of experiments with mammalian-transmissible, possibly highly virulent influenza viruses remains high even if some aspects of their laboratory biology are reass...

A new Overlay for Plaquing Animal Viruses

Animal models for pathogenic Neisseria species.

The development and use of various animal models in the early 1970s helped renew interest in the immunobiology of Neisseria gonorrhoeae and N. meningitidis. This research also provoked controversy concerning which infection model provided the most useful information. Certainly, the human host or isolated organ cultures provided a relevant test system for neisserial infections; however, these mo...