Amoxycillin and Ampicillin

Comparison of ampicillin and amoxycillin in acute or chronic bronchitis.

Pharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin.

Bacampicillin, a new oral prodrug which in vivo is rapidly transformed to ampicillin, was compared with ampicillin, pivampicillin, and amoxycillin in a randomized cross-over study on 11 healthy volunteers. All drugs were given in oral doses equimolar to 400 mg of bacampicillin (800 mumol). The mean of the individual peak concentrations in serum was 8.3 mug/ml for bacampicillin, 7.1 mug/ml for p...

Triple crossover study on absorption and excretion of ampicillin, talampicillin, and amoxycillin.

Talampicillin and amoxycillin were shown to be absorbed twice as well as ampicillin in a triple crossover experiment.

Triple crossover study on absorption and excretion of ampicillin, pivampicillin, and amoxycillin.

The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicillin was given with breakfast. The mean half-life times were nearly identical fo...

Comparative effects of amoxycillin and ampicillin in the treatment of experimental mouse infections.

Amoxycillin was significantly more active than ampicillin in the treatment of intraperitoneal mouse infections when administered by oral and parenteral routes, although the causal bacteria were equally susceptible in vitro to the two penicillins. Amoxycillin produced higher antibiotic blood concentrations in mice than ampicillin after oral administration, and this was a possible explanation for...