Alveolar permeability and stretch: too far, too fast

Alveolar permeability and stretch: too far, too fast.

M echanical ventilation is the most widely used therapy in intensive care units and the cornerstone treatment for patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) [1]. Although essential for successful management of respiratory failure, mechanical ventilation can also exacerbate or even directly injure the lungs [2, 3]. This damage, commonly referred to as ve...

A sternotomy too far.

Median sternotomy has been used for a long time as a standard approach for many cardiothoracic procedures in children. Many complications have been reported to result from this approach with different incidences. Iatrogenic diaphragmatic hernia has not been reported as a definite complication of such approach. This paper presents a case report for a 14-month-old boy with iatrogenic diaphragmati...

Is spending on proton beam therapy for cancer going too far, too fast?

Fast Clustering with Lower Bounds: No Customer too Far, No Shop too Small

We study the LowerBoundedCenter (LBC) problem, which is a clustering problem that can be viewed as a variant of the k-Center problem. In the LBC problem, we are given a set of points P in a metric space and a lower bound λ, and the goal is to select a set C ⊆ P of centers and an assignment that maps each point in P to a center of C such that each center of C is assigned at least λ points. The p...

Not too late, not too fast!!

This editorial refers to ‘A simplified biventricular defibrillator with fixed long detection intervals reduces implantable cardioverter defibrillator (ICD) interventions and heart failure hospitalizations in patients with non-ischaemic cardiomyopathy implanted for primary prevention: the RELEVANT [Role of long dEtection window programming in patients with LEft VentriculAr dysfunction, Non-ische...