Alternative Procedures for Reducing Allogeneic Blood Transfusion in Elective Orthopedic Surgery

Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?

Studies have shown that antifibrinolytic (aprotinin, tranexamic acid, epsilon-aminocaproic acid) reduce blood loss in orthopedic surgery. However, most lacked sufficient power to evaluate the efficacy and safety on clinical outcomes. This meta-analysis aims to evaluate whether intravenous antifibrinolytics, when compared with placebo, reduce perioperative allogeneic erythrocyte transfusion requ...

Methods of reducing allogeneic blood demand in orthopedic surgery.

Despite advances in this field, allogeneic blood transfusion still carries a lot of risk; the availability of heterologous blood is also constantly decreasing. We describe the most popular methods for reducing the allogeneic blood requirement. Basic information is presented about the physiological mechanisms of compensation for intraoperative blood loss, which can be compromised by respiratory ...

Reducing the risk of allogeneic blood transfusion.

The restricted use of allogeneic blood transfusions has been accepted throughout the world as important in reducing risk, particularly of the transmission of infectious diseases. In orthopedic surgery reduced use of allogeneic transfusions has been shown to prevent both early and late postoperative infection. In this issue (page 310) Brian Feagan and colleagues describe transfusion practices an...

Autologous transfusion and reducing allogeneic blood exposure.

Reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery.

At present, individual techniques, including intraoperative acute normovolemic hemodilution, use of tranexamic acid, use of intrathecal morphine, proper positioning, and modification of operative techniques, seem most promising for reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery. Other techniques including preoperative autologous pre...