Altered diffusion tensor imaging (DTI) parameters in brain parenchyma after traumatic brain injury

Abstract Aim of study To evaluate the role diffuse tensor imaging (DTI) in detecting structural alterations following TBI with persistent symptoms without findings on conventional imaging. Methods This was a prospective that enrolled total 30 individuals (12 females and 18 males), 6 control no history trauma 24 previous trauma. All subjects underwent brain MRI DTI. The eigenvalues genue splenium corpus callosum (CC), superior longitudinal fasciculus (SLF), inferior (ILF), corticospinal tract (CS), arcuate (AF) were measured bilaterally all cases using suitable region interest fraction anisotropy (FA), mean diffusivity (MD), calculated. FA MD values compared between patients subjects. Diagnostic accuracy calculated for FA, combined. Sensitivity Specificity determined from curve PPV, NPV calculation through cross-tabulation. Result As controls, significantly decreased increased CC CS. For Combined & differentiating there statistically significant difference SLF, AF, genue, splenium, ILF CS as p value < 0.05. Conclusions DTI parameters is promising tool detection subtle parenchymal changes who have evident abnormalities MRI. Furthermore combined use shows better diagnostic differentiation patient.