Alpha-stat versus pH-stat: We do not pay it much mind
نویسندگان
چکیده
منابع مشابه
Effects of pH management during deep hypothermic bypass on cerebral microcirculation: alpha-stat versus pH-stat.
OBJECTIVE There is controversy regarding the optimal pH strategy during deep hypothermic bypass in children. We directly visualized the effects of the pH-stat and alpha-stat strategy on cerebral microcirculation (including leukocyte/endothelial cell interactions) in a piglet model using intravital fluorescence microscopy. METHODS Two groups of 5 piglets (mean weight 9.6+/-1.3 kg) with a crani...
متن کاملpH-stat vs alpha-stat Management During DHCA
Despite a half century of research and the implementation of various risk-reduction strategies among clinicians and basic scientists, patients continue to experience strokes and cognitive dysfunction related to the use of deep hypothermic circulatory arrest (DHCA) during cardiopulmonary bypass (CPB) for cardiac surgery. The debate over optimal blood gas management during DHCA continues. Most cl...
متن کاملLECTURE Alpha-Stat versus pH-Stat: Implications for the Brain During Cardiopulmonary Bypass
During cardiac surgery, systemic hypothermia is often utilized to augment cardioplegic myocardial preservation. The ensuing reduction in metabolic activity is directly related to the decrease in temperature as predicted by Vant Hoff's law. Lowered metabolic-activity decreases oxygen utilization, thus increasing tissue tolerance for reductions in oxygen delivery. Among numerous other physiologic...
متن کاملEffects of pH management during selective antegrade cerebral perfusion on cerebral microcirculation and metabolism: alpha-stat versus pH-stat.
BACKGROUND Selective cerebral perfusion (SCP) is used for extending the period during which surgical procedures can be safely performed. We sought to determine the direct effects of pH management on cerebral microcirculation and metabolism during SCP. METHODS An experimental SCP porcine model was created by selectively allowing cold perfusate only into the bicarotid brachiocephalic trunk duri...
متن کاملEffect of alpha-stat versus pH-stat strategy on oxyhemoglobin dissociation and whole-body oxygen consumption during hypothermic cardiopulmonary bypass.
To determine whether alpha-stat or pH-stat strategy should be used, 20 patients undergoing coronary artery bypass grafting during moderate hypothermic hemodilutional cardiopulmonary bypass were studied. The carbon dioxide management during bypass was randomly done according to alpha-stat strategy in 10 patients (i.e., temperature-uncorrected PaCO2 was kept near 40 mm Hg and uncorrected pHa was ...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2018
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2018.03.088