Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Since the 1960s membrane-bound enzyme alkaline phosphatase (ALP) has been utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents, and even surface of nanocarriers, this enables design delivery systems that can alter their properties body on demand. Anionic nanocarriers exhibiting bioinert to interactive once having reached target site as due an ALP-triggered cleavage anionic groups charge converts cationic improving for instance cellular uptake. Moreover, features such accumulation at or a targeted release triggered by ALP be introduced. In addition, is improve potential numerous diagnostic systems. Within review, one provides overview about activity, selectivity, distribution enzyme, well great variety applications diagnostics making use it.