منابع مشابه
Alcohol-Induced Liver Injury
There are three phases of alcoholic liver disease: fatty liver, which is usually reversible with abstinence; alcoholic hepatitis, or liver inflammation; and cirrhosis, or scarring of the liver. Patients frequently have more than one type of liver disease, such as coexisting fatty liver and alcoholic hepatitis or alcoholic hepatitis together with cirrhosis. Patients with both cirrhosis and alcoh...
متن کاملAcute Alcohol-Induced Liver Injury
Alcohol consumption is customary in most cultures and alcohol abuse is common worldwide. For example, more than 50% of Americans consume alcohol, with an estimated 23.1% of Americans participating in heavy and/or binge drinking at least once a month. A safe and effective therapy for alcoholic liver disease (ALD) in humans is still elusive, despite significant advances in our understanding of ho...
متن کاملConcerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver.
UNLABELLED Peroxiredoxins (Prxs) are peroxidases that catalyze the reduction of reactive oxygen species (ROS). The active site cysteine residue of members of the 2-Cys Prx subgroup (Prx I to IV) of Prxs is hyperoxidized to cysteine sulfinic acid (Cys-SO(2) ) during catalysis with concomitant loss of peroxidase activity. Reactivation of the hyperoxidized Prx is catalyzed by sulfiredoxin (Srx). E...
متن کاملAlcohol-induced liver disease: when fat and oxidative stress meet.
Reactive oxygen species (ROS) act as signaling intermediates regulating multiple cellular processes. The fate and disposal of the signaling species are determined by the actions of antioxidants, particularly glutathione (GSH). The mitochondrial pool of GSH (mGSH) arises from the transport of cytosol GSH by a specific mitochondrial carrier and is responsible for the maintenance of a healthy comp...
متن کاملHepatoprotective Effects of Curcumin Nanomicells in Alcohol-induced Liver Injury: Comparison with Curcumin and Silymarin in Mice Model
Background: Curcumin ameloriates liver damages but its poor absorption, rapid metabolism, and side effects at high doses may limit its clinical applications Objective: This study aimed to evaluate the protective and regenerative effects of Curcumin Nanomicells on alcohol-induced chronic liver injuries in mice. These effects were compared with Curcumin and Silymarin in the same model. Method...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2006
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.20957