Albumin And Hypoalbuminemia: Relevance in Orthopaedic Surgery

Albumin in Health and Disease: Causes and Treatment of Hypoalbuminemia*

When disease leads to moderate or severe hypoalbuminemia (i.e., albumin <2 mg/dl), detrimental consequences may influence the clinical course and negatively impact the prognosis. In fact, multiple human studies and a few veterinary ones have shown hypoalbuminemia to be correlated with a poorer prognosis. Treatment considerations for hypoalbuminemic patients should address the consequences and c...

In-vivo oxidized albumin– a pro-inflammatory agent in hypoalbuminemia

Hypoalbuminemia of Hemodialysis (HD) patients is an independent cardiovascular risk factor, however, there is no mechanistic explanation between hypoalbuminemia and vascular injury. In the event of oxidative stress and inflammation to which HD patients are exposed, albumin is oxidized and undetected by common laboratory methods, rendering an apparent hypoalbuminemia. We wanted to show that thes...

Orthopaedic surgery.

Ethics in orthopaedic surgery.

©2005 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.87B11. 16936 $2.00 J Bone Joint Surg [Br] 2005;87-B:1449-51. Medicine, law and religion are the three traditional learned professions. With professionalism should come both privilege and responsibility. As surgeons we study to achieve specialised knowledge and supplement this with training and experience. Our patien...

Ximelagatran in orthopaedic surgery.

Ximelagatran represents the first new oral anticoagulant since the introduction of warfarin almost 60 years ago, and has been evaluated for the treatment and prevention of a range of venous and arterial thromboembolic disorders. The MElagatran THRomboprophylaxis in Orthopaedic surgery (METHRO) and EXpanded PRophylaxis Evaluation Surgery Study (EXPRESS) studies have investigated the efficacy and...