منابع مشابه
Role of G proteins in agonist-induced Ca2+ sensitization of tracheal smooth muscle.
Increased sensitivity to intracellular Ca2+ concentration ([Ca2+]) is an important mechanism for agonist-induced contraction of airway smooth muscle, but the signal transduction pathways involved are uncertain. We studied Ca2+ sensitization with acetylcholine (ACh) and endothelin (ET)-1 in porcine tracheal smooth muscle by measuring contractions at a constant [Ca2+] in strips permeabilized with...
متن کاملAugmented Agonist-induced Ca2+-Sensitization of Coronary Artery Contraction in Genetically Hypertensive Rats
The Ca2" responsiveness of vascular smooth muscle myofilaments is not unique: it is increased during neuro-humoral activation and decreased during /3-adrenergic stimulation. In this study we tested whether an augmented Ca2" responsiveness of smooth muscle myofilaments may contribute to the increased coronary tone observed in hypertension using /3-escin-permeabilized coronary arteries from 3-mo-...
متن کاملInteraction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery
AIMS We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction with the rho/rho-kinase pathway. METHODS AND RESULTS Intra-pulmonary arteries (IPAs) and cultured pulmonary artery smooth muscle cells (PASMC) were obtained from rat. Expression of srcFK was determined at the mRNA and protein levels. Ca2+...
متن کاملCa2+ sensitization of smooth muscle contractility induced by ruthenium red.
The effects of ruthenium red (RuR) on contractility were examined in skinned fibers of guinea pig smooth muscles, where sarcoplasmic reticulum function was destroyed by treatment with A-23187. Contractions of skinned fibers of the urinary bladder were enhanced by RuR in a concentration-dependent manner (EC50 = 60 μM at pCa 6.0). The magnitude of contraction at pCa 6.0 was increased to 320% of c...
متن کاملPhospholipase C-γ Is Required for Agonist-Induced Ca2+ Entry
ates rapid Ca store release through the activation of InsP3 receptors (IP3R) in the endoplasmic reticulum (ER) membrane (Berridge et al., 2000). Following this initial Randen L. Patterson,1,6 Damian B. van Rossum,2,6 Diana L. Ford,2 Kenneth J. Hurt,1 Sun Sik Bae,3 Pann-Ghill Suh,3 Tomohiro Kurosaki,4 Ca store-release, external Ca enters through plasma Solomon H. Snyder,1,5 and Donald L. Gill2 m...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51125-8