Aggregated carbon dots?loaded macrophages treat sepsis by eliminating multidrug?resistant bacteria and attenuating inflammation

Sepsis, caused by uncontrollable infection and inflammatory response, leads to more than 30 million infected patients results in high morbidity worldwide every year. Currently, no efficient approaches have been developed for sepsis therapy due antimicrobial resistance storm. Here, we report macrophages loaded with aggregated carbon dots (ACDs) the lysosome, termed MCDs, treat immunosuppressive mice. The ACDs are constructed negative CDs amine-abundant polyethyleneimine (PEI), enabling them bear strong antibacterial ability enhanced photoluminescent efficacy. specifically located macrophage lysosomes, efficiently enhancing multidrug-resistant bacteria-killing of MCDs. More importantly, MCDs possess superior anti-inflammatory effects such as reducing number pro-inflammatory (M1) stimulating (M2) macrophages. These upregulate cytokines (TNF-?, IL-1?, IL-4, IL-10), ultimately resulting increased survival. Our work provides an intelligent approach overcoming bacteria-induced from paves a new avenue on employing nanoparticle-loaded cells combating inflammation-related infection.