Ageing and Neurodegenerative Disorders

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ageing and Neurodegenerative Disorders

1Life, Health and Environmental Science Department, University of L’Aquila, 67100 L’Aquila, Italy 2Neuropsychology Unit, IRCCS Santa Lucia Foundation, 00179 Rome, Italy 3School of Life & Health Sciences, Aston University, Birmingham, West Midlands B15, UK 4Division of Behavioral Neurology, Department of Neurology and Alzheimer’s Disease Research Center, National Cheng Kung University Hospital, ...

متن کامل

Ghrelin: A link between ageing, metabolism and neurodegenerative disorders

Along with the increase in life expectancy over the last century comes the increased risk for development of age-related disorders, including metabolic and neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases. These chronic disorders share two main characteristics: 1) neuronal loss in motor, sensory or cognitive systems, leading to cognitive and motor decline; a...

متن کامل

PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders.

PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in cells. Recent work highlighted that PGC1α can also modulate the composition and functions of individual mitochondria. Therefore, it is emerging that PGC1α is controlling global oxidative metabolism by performing two types of remodelling: (1) cellular remodelling through mitochondrial biogenesis, and ...

متن کامل

Oxidative Stress in Neurodegenerative Diseases and Ageing

Since Denham Harman has proposed the free radical theory of ageing, the knowledge and the understanding of the mechanisms of ageing process have increased remarkably. Over decades, this unavoidable phenomenon has also been linked, both causatively and consequently, with the development of several abnormalities, currently known as the “agerelated diseases.” Oxidative Medicine and Cellular Longev...

متن کامل

Autophagy and neurodegenerative disorders

Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Behavioural Neurology

سال: 2015

ISSN: 0953-4180,1875-8584

DOI: 10.1155/2015/149532