Acute Metabolic Alkalosis Enhances Response of C3H Mouse Mammary Tumors to the Weak Base Mitoxantrone
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چکیده
منابع مشابه
Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone.
Uptake of weak acid and weak base chemotherapeutic drugs by tumors is greatly influenced by the tumor extracellular/interstitial pH (pH(e)), the intracellular pH (pH(i)) maintained by the tumor cells, and by the ionization properties of the drug itself. The acid-outside plasmalemmal pH gradient in tumors acts to exclude weak base drugs like the anthracyclines, anthraquinones, and vinca alkaloid...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2001
ISSN: 1476-5586
DOI: 10.1038/sj.neo.7900151