A unified approach to false discovery rate estimation
نویسندگان
چکیده
منابع مشابه
Improving false discovery rate estimation
MOTIVATION Recent attempts to account for multiple testing in the analysis of microarray data have focused on controlling the false discovery rate (FDR). However, rigorous control of the FDR at a preselected level is often impractical. Consequently, it has been suggested to use the q-value as an estimate of the proportion of false discoveries among a set of significant findings. However, such a...
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Constraint-based Bayesian network (BN) structure learning algorithms typically control the False Positive Rate (FPR) of their skeleton identification phase. The False Discovery Rate (FDR), however, may be of greater interest and methods for its utilization by these algorithms have been recently devised. We present a unified approach to BN skeleton identification FDR estimation and control and e...
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MOTIVATION Presently available methods that use p-values to estimate or control the false discovery rate (FDR) implicitly assume that p-values are continuously distributed and based on two-sided tests. Therefore, it is difficult to reliably estimate the FDR when p-values are discrete or based on one-sided tests. RESULTS A simple and robust method to estimate the FDR is proposed. The proposed ...
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With the advancement in proteomics separation techniques and improvements in mass analyzers, the data generated in a mass-spectrometry based proteomics experiment is rising exponentially. Such voluminous datasets necessitate automated computational tools for high-throughput data analysis and appropriate statistical control. The data is searched using one or more of the several popular database ...
متن کاملStrong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach
The false discovery rate (FDR) is a multiple hypothesis testing quantity that describes the expected proportion of false positive results among all rejected null hypotheses. Benjamini and Hochberg introduced this quantity and proved that a particular step-up p-value method controls the FDR. Storey introduced a point estimate of the FDR for fixed significance regions. The former approach conserv...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2008
ISSN: 1471-2105
DOI: 10.1186/1471-2105-9-303