A systems-biology approach to understanding the ciliopathy disorders

A systems biology approach to understanding atherosclerosis

Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering regulatory networks underlying the response of many differen...

SYSTEMS BIOLOGY: The Solution to Understanding Alcohol-Induced Disorders?

from linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar

chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...

An Evolutionary Biology Approach to Understanding Neurological Disorders

Many common human neurological disorders, including epilepsy, Alzheimer’s disease, Parkinson’s disease, autism spectrum disorders, and schizophrenia show complex heritability and genetics. While studies of single-gene diseases typically provide a more straightforward opportunity to understand the underlying molecular mechanisms of disease, complex diseases are more common and inherently more di...

Metabolic phenotyping and systems biology approaches to understanding neurological disorders

The development of high-throughput metabolic profiling and the study of the metabolome are particularly important in brain research where small molecules or metabolites play fundamental signalling roles: neurotransmitters, signalling lipids, osmolytes and even ions. Metabolic profiling has shown that metabolic perturbations in the brain go beyond alterations of neurotransmission and that variat...