A single dose of dalteparin effectively prevents clotting during haemodialysis

A single dose of dalteparin effectively prevents clotting during haemodialysis.

BACKGROUND A single bolus dose of LMW heparin at the start of haemodialysis effectively prevents clot formation in the dialyser and bubble trap. However, there are few studies on the appropriate dosage of LMW heparins in haemodialysis. Therefore we examined the relationship between the anticoagulant effect of dalteparin and clinical clotting during haemodialysis. METHODS We performed an open,...

Activated clotting time (ACT)-guided intravenous dalteparin dosing during percutaneous coronary intervention.

BACKGROUND The activated clotting time (ACT) has been reported to be sensitive to the anticoagulant activity of the low-molecular weight heparin dalteparin following intravenous (IV) administration. OBJECTIVE To evaluate the feasibility of an ACT-guided dalteparin dose adjustment strategy during percutaneous coronary intervention (PCI). METHODS This was a retrospective study of 104 consecut...

Single-dose daptomycin pharmacokinetics in chronic haemodialysis patients.

BACKGROUND Daptomycin has concentration-dependent antibacterial activity against Gram-positive bacteria. Its use is increasing in haemodialysis units. The manufacturer recommends a 4-6-mg/kg dose administered every 48 hrs for patients receiving haemodialysis. However, there are no published data about daptomycin pharmacokinetics and clearance during haemodialysis. The recommended dosing regimen...

Serial Myocardial Imaging after a Single Dose of Thallium-201

Although thallium-201 exercise scintigraphy has been established for the detection of myocardial ischemia and viability, little is known regarding the myocardial thallium-201 kinetics during angioplasty. Herein, we report a 77-year old man with angina pectoris, in whom serial myocardial imaging after a single dose of thallium-201 was helpful in identifying not only the culprit lesion and myocar...

In West Africa, Single-Dose Antibiotic Treats Vaginal Discharge as Effectively as Multiple-Dose Treatment