Aβ Secretion and Plaque Formation Depend on Autophagy
نویسندگان
چکیده
منابع مشابه
Aβ secretion and plaque formation depend on autophagy.
Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To investigate the role of autophagy in Aβ pathology in vivo, we crossed amyloid precursor protein (APP) transgenic mice with mice lacking autoph...
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Recently, certain C-terminal fragments (CTFs) of Aβ42 have been shown to be effective inhibitors of Aβ42 toxicity. Here, we examine the interactions between the shortest CTF in the original series, Aβ(39-42), and full-length Aβ. Mass spectrometry results indicate that Aβ(39-42) binds directly to Aβ monomers and to the n = 2, 4, and 6 oligomers. The Aβ42:Aβ(39-42) complex is further probed using...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.08.042