A REVIEW ON THE SOLID ORAL DOSAGE FORM FOR PEDIATRICS, REGULATORY ASPECTS, CHALLENGES INVOLVED DURING THE FORMULATION, AND TOXICITY OF THE EXCIPIENTS USED IN PEDIATRIC FORMULATION

Designing an appropriate dosage form in medical treatment for the pediatric population is very challenging. The major challenges faced during designing oral solid pediatrics are also prerequisites development of form, and they are, administering drug according to body weight taste masking, which followed by other factors like safety excipients, size so on. Oral forms mini-tablets, soluble films, orally disintegrating tablets a few promising use population. obstacles, such as physiological differences between various age groups, excipient safety, technology requirements, low profitability, clinical trial limitations, regulatory ambiguity all have impact on development. Recent advancement formulations has been made due new regulations, more financial opportunities, novel collaborative research programs. A shift pattern towards emphasis innovative preparations, dispersible, flexible, well multi-particulate dose forms, some advanceme nts. Such advancements allowed flexibility dose, easy administration, improved medication formulation acceptance pediatrics. In consideration pediatrics, issues suitability, selection, prospects modified release or fixed-dose combinations, palatability, acceptability, were reviewed current manuscript.