A PHD12–Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
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چکیده
منابع مشابه
A PHD12–Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
Neural crest cells form within the neural tube and then undergo an epithelial to mesenchymal transition (EMT) to initiate migration to distant locations. The transcriptional repressor Snail2 has been implicated in neural crest EMT via an as of yet unknown mechanism. We report that the adaptor protein PHD12 is highly expressed before neural crest EMT. At cranial levels, loss of PHD12 phenocopies...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201203098