A New Muscle Disuse Model Using A Removable Tissue-engineering Muscle

Establishing a new animal model for muscle regeneration studies

Skeletal muscle injuries are one of the most common problems in the worldwide which impose a substantial financial burden to the health care system.  Accordingly, it widely accepted that muscle regeneration is a promising approach that can be used to treat muscle injury patients. However, the underlying mechanisms of muscle regeneration have yet to be elucidated. The muscle structure and muscle...

Applications of Small Molecules in Muscle Tissue Engineering

Introduction: Skeletal muscles account for about 40% of the total body weight. Every year, hundreds of people lose at least part of their muscle tissue due to illness, war, and accidents. This can lead to disruption of activities such as breathing, movement, and social life. To this end, various therapeutic strategies such as medication therapy, cell therapy and tissue transplantation have been...

A new approach to tissue engineering of vascularized skeletal muscle

Tissue Engineering of skeletal muscle tissue still remains a major challenge. Every neo-tissue construct of clinically relevant dimensions is highly dependent on an intrinsic vascularisation overcoming the limitations of diffusion conditioned survival. Approaches incorporating the arteriovenous-loop model might bring further advances to the generation of vascularised skeletal muscle tissue. In ...

Engineering Cardiac Muscle Tissue

The origin of the term tissue engineering is not clear, but a 1985 proposal of Y.C. Fung to the National Science Foundation of the United States for a Center for the Engineering of Living Tissues and 2 conferences organized by the National Science Foundation in 1987 and 1988 are generally accepted as the origin of this lively and rapidly growing research field (The Emergence of Tissue Engineeri...

Disuse TWEAKs muscle loss