A multimodal sevoflurane-based sedation regimen in combination with targeted temperature management in post-cardiac arrest patients reduces the incidence of delirium: An observational propensity score-matched study

BackgroundRecent studies suggest that volatile anaesthetics are safe, efficient, and reliable alternatives to the use of intravenous for out-of-hospital cardiac arrest (OHCA) patients admitted intensive care unit (ICU). We hypothesised may reduce incidence delirium rather than sedatives. This retrospective study aimed investigate whether sevoflurane combined with higher targeted temperature management could decrease when compared lower management.MethodsUsing a propensity score-matched analysis, we retrospectively target (32?34 °C) method along sedation (TTM-33/IV) modified (34?36 (mTTM-36/sevo). used confusion assessment ICU measure delirium. calculated time-dependent risk on using multivariate Cox regression model.ResultsThe was significantly (p = 0.001) in OHCA mTTM-36/sevo group (9/56, 16.1%) those TTM-33/IV (25/67, 37.3%). Mechanical ventilation lengths stay < hospital 0.04) were shorter group. Patients required more midazolam, propofol, fentanyl. observed no significant difference mortality.ConclusionA multimodal sevoflurane-based regimen together resulted duration mechanical length did treatment classical cooling protocol.