A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes
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چکیده
منابع مشابه
A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes☆
The glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia disrupts cell function and contributes to many pathologies, including those associated with diabetes and aging. Intracellular glycation occurs after the generation of the reactive 1,2-dicarbonyls methylglyoxal and glyoxal, and disruption of mitochondrial function is associated with hyperglycemia. However, t...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2014
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2013.11.025