A facile method for the labeling of proteins with zirconium isotopes

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A facile method for the labeling of proteins with zirconium isotopes.

To label proteins with positron emitters with a half-life in the order of days, a method has been developed to label proteins with zirconium (Zr)-isotopes. Therefore, the bifunctional chelating agent desferal (Df) was coupled to albumins via a thioether bond. Labeling of the premodified proteins was easily performed by addition of these proteins to freeze-dried Zr-oxalate. This labeling was eff...

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ژورنال

عنوان ژورنال: Nuclear Medicine and Biology

سال: 1996

ISSN: 0969-8051

DOI: 10.1016/0969-8051(96)00020-0