A facile approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones using a microwave promoted Biginelli protocol in ionic liquid
نویسندگان
چکیده
منابع مشابه
Solvent-free and one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones using ionic liquid N,N-diethyl-N-sulfoethanammonium chloride {[Et3N–SO3H]Cl} as a green catalyst.
In this work, the ionic liquid triethylamine-bonded sulfonic acid {[Et3N–SO3H]Cl}, N,N-diethyl-N-sulfoethanammonium chloride was used as a green acidic homogeneous catalyst to synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones as two categories of heterocycles, from aldehyde, dicarbonyl compound and urea or thiourea throughout the one-pot three components cycloc...
متن کاملSynthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions
The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized dihydropyrimidone-α-acyloxycarboxamide compounds were obtained in good to excellent yields. In a first reaction step, different 3,4-dihydropyrimidin-2(1H...
متن کاملMicrowave-assisted Oxidation of 3,4-Dihydropyrimidin-2(1H)-ones
A new facile cost-effective method for the oxidation of acetyl and carboethoxy derivatives of 3,4dihydropyrimidin-2(1H)-ones (DHPMs) by using potassium peroxydisulfate in water as solvent under microwave irradiation has been developed. Whereas the presence of the acetyl group instead of the carboethoxy group in position 5 decreases the rate of oxidation, the nature of the additional subtituent ...
متن کاملsolvent-free and one-pot biginelli synthesis of 3,4-dihydropyrimidin-2(1h)-ones and 3,4-dihydropyrimidin-2(1h)-thiones using ionic liquid n,n-diethyl-n-sulfoethanammonium chloride {[et3n–so3h]cl} as a green catalyst.
in this work, the ionic liquid triethylamine-bonded sulfonic acid {[et3n–so3h]cl}, n,n-diethyl-n-sulfoethanammonium chloride was used as a green acidic homogeneous catalyst to synthesis of 3,4-dihydropyrimidin-2(1h)-ones and 3,4-dihydropyrimidin-2(1h)-thiones as two categories of heterocycles, from aldehyde, dicarbonyl compound and urea or thiourea throughout the one-pot three components cycloc...
متن کاملAmmonium Trifluoroacetate-Mediated Synthesis of 3,4-dihydropyrimidin-2(1H)-ones
A simple and economic synthesis of 3,4-dihydropyrimidin-2(1H)-ones using ammonium trifluoroacetate as catalyst and as solid support is accomplished. Easy workup procedure for the synthesis of title compounds is well arrived at and is well documented.
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ژورنال
عنوان ژورنال: Journal of Chemical Sciences
سال: 2012
ISSN: 0974-3626,0973-7103
DOI: 10.1007/s12039-012-0278-5