917 CD44 and p38 participate in regulating the pro-fibrotic capability of dermal fibroblasts during skin wound healing

Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts

BACKGROUND Scleroderma (systemic sclerosis; SSc) is a clinically heterogeneous and often lethal acquired disorder of the connective tissue that is characterized by vascular, immune/inflammatory and fibrotic manifestations. Tissue fibrosis is the main cause of morbidity and mortality in SSc and an unmet medical challenge, mostly because of our limited understanding of the molecular factors and s...

Histopathological effects of nanosilver (Ag-NPs) in liver after dermal exposure during wound healing

Objective(s): With the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (Ag-Nps). These nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. However, little attention has been paid to the toxicity of nanosilver wound dressing. This study was designed to investigate the ...

Fibrotic Response Healing by Regulating the Inflammatory and CD44 Is Critically Involved in Infarct

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at small circular (2 mm) wound sites. At P2, new HFs formed in back skin, but HF formation was markedly decreased by P21. Neonatal tail also formed wound-associated HFs, al...

assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.

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