3SC54 Intermediate structure and hydroxylation mechanism of xanthine oxidoreductase
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منابع مشابه
Crystal structure and mechanism of action of the xanthine oxidase-related aldehyde oxidoreductase from Desulfovibrio gigas.
The crystal structure of the aldehyde oxidoreductase (Mop) from the sulphate-reducing bacterium Destdjovibrio gigas has been analysed and refined to 1.8A (0.18 nm) resolution in its native ‘desulpho’ form, as well as in ‘resulphurated’, oxidized, reduced and alcohol-bound forms [1,2], allowing a detailed look at several structural aspects relevant to catalysis. In analogy with eukaryotic xanthi...
متن کاملThe crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition.
Molybdenum is widely distributed in biology and is usually found as a mononuclear metal center in the active sites of many enzymes catalyzing oxygen atom transfer. The molybdenum hydroxylases are distinct from other biological systems catalyzing hydroxylation reactions in that the oxygen atom incorporated into the product is derived from water rather than molecular oxygen. Here, we present the ...
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The recently solved X-ray crystal structure of the molybdenum-containing arsenite ox idoreductase from Alcaligenes fa ecalis, is discussed, keeping in view the known mechanistic and spectroscopic information regarding the protein in a structural context. In addi tion, recent mechan istic studies of );,janthine oxidase are covered , with the conclusion that the reaction meclianism is initiated b...
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Yliopistopaino The truth is rarely pure and never simple.
متن کاملXanthine oxidoreductase in respiratory and cardiovascular disorders.
In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders such as acute lung injury, ischemia-reperfusion injury, atherosclerosis, heart failure, and arterial hypertension. Although much remains to be clarified about the regulation and signal...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2004
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.44.s28_4