2D-QSAR Studies of Substituted Pyrazolone Derivatives as Anti-Inflammatory Agents
نویسندگان
چکیده
منابع مشابه
2D QSAR Study of Substituted 2-Phenyl- Benzimidazole Derivatives as Potent Anti Allergic Agents
A set of forty one substituted-2-phenyl-benzimidazole derivatives with anti-allergic activity was subjected to the two dimensional quantitative structure activity relationships studies using V life molecular design suite 3.5. Drug Designing module contain various combinations of thermodynamic, electronic, topological and spatial descriptors.Substituted-2-phenyl-benzimidazole was taken as the le...
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Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
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A novel series of nine indolyl pyrazoline pharmacophore were synthesized by the reaction of hydrazine hydrate derivatives with the synthesized chalcones (C4,C5,C6). The chalcones were synthesized by the Claisen Schimdt condensation method. These pyrazoline derivatives were evaluated for anti-inflammatory activity using Carrageenan induced paw oedema method. The activity profile reveals that the...
متن کاملQSAR Studies of Some Synthetic Structurally Related Androstene Derivatives as Anti-Inflammatory Agents
The use of steroids in the acute and emergency conditions of inflammation is well established. Most of the time they are given chronically to the patients with arthritis. The present study focuses on developing substantial quantitative structure activity relationship models of certain steroidal derivatives reported to be as anti-inflammatory agents. The QSAR models of androstene derivatives wer...
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ژورنال
عنوان ژورنال: Medicinal chemistry
سال: 2012
ISSN: 2161-0444
DOI: 10.4172/2161-0444.1000127