#2827 RISK FACTORS FOR VENOUS AND ARTERIAL THROMBOEMBOLIC COMPLICATIONS IN NEPHROTIC SYNDROME: A COHORT STUDY

Abstract Background and Aims Venous thromboembolic events (VTE) arterial (ATE) are serious complications of nephrotic syndrome (NS). Studies needed to identify patients at high risk for VTE ATE. We aimed describe patient-related factors ATE in a mixed population patients. Method This multicentre cohort study included adult NS with plasma albumin <30 g/l urine albumin-creatinine ratio (uACR) >2,200 mg/g, who were hospitalized or followed an outpatient clinic the Central Denmark Region between 2014-2018. Using computerized data extraction from medical files, identified until dialysis, transplantation, end study. recorded comorbidities, family history, renal parameters and, histological diagnosis index time as well as, medication VTE/ATE event. Categorical continues compared using difference mean respectively. The incidence event is presented rate. Results Among 531 patients, 22 had their first 46 within observation year (median 0.8 vs. 0.9 years). Incidence rates 11 per 1000 person-years (95% CI: 7-17) 24 18-32) Plasma-albumin levels (27 g/l) identical group time, but eGFR was lower (Table 1), uACR higher uACR; 1055 mg/g 2752 mg/g). Hypercholesterolemia more prevalent among VTE, they often on corticosteroids than Diabetes, hypertension, heart failure baseline resulting increased CHADS-VASC score. Mortality (83%) (32%). Conclusion Patients have Corticosteroid use common associated uACR, CHADS2-VASC score, mortality VTE.