(249) Seminal Parameters after Tamsulosin Oral Intake in Young Fertile Men

Abstract Introduction Fertility and birth control is a worldwide health concerning since it an important issue regarding economic, religious, or social impacts for couples. Women have plenty options oral hormonal anticonception were introduced in daily practice. However, men remain restricted to condoms vasectomy surgery until now 50% of natural conceptions are considered not desired. Many been proposed contraception (hormonal non-hormonal strategies) but still none them seems be safe about efficacy, side effects, reversibility. Alpha-blockers shown effects ejaculation matter debate if those from retrograde impaired sperm emission. Actual data suggest specific alfa-1A blockage effect may achieve azoospermia, however clear when occurs the exact mechanism disorder. Objective The main objective this study determine how semen analysis on concentration affected by tamsulosin 0,8mg 24-hour range after intake. Methods 34 between 18-45 years-old recruited consent with inclusion criteria OMS normal parameters ability masturbation collect samples. Exclusion hepatic disorders, neurological renal inability masturbation, previous concomitant use testosterone other anabolic steroids possible medications interaction. 31 individuals met including designated intake sample 4, 8, 12, 16,20 24 hours different moments 6 medication serum concentrations. Minimum interval each 1 week. In case any participant urine was performed ejaculation. Samples determined volume concentration. Side Protocol approved at local ethical committee (CAAE: 26124719.2.0000.0082). Results Low compared basal achieved 29/31 (93,6%) while azoospermia diagnosed 25/31 (80,7%). Only subject identified as absolute azoospermia. Intervals achievement varied 8 16 Most subjects returned medication. most disorder discomfort, minor headache dizziness bothering incapacitant. Conclusions Ejaculation correspond emission study. This could option further studies male without risks spermatogenesis approach reversibility well tolerated effects. Disclosure No