235 PPAR-alpha deficiency drives altered bacterial skin colonization and abnormal eicosanoid skin composition

Bacterial skin colonization and infections in patients with atopic dermatitis.

Atopic Dermatitis is a chronic inflammatory skin disease that affects a large number of children and adults. The disease results from an interaction between genetic predisposition, host environment, skin barrier defects, and immunological factors. A major aggravating factor associated with Atopic Dermatitis is the presence of microorganisms on the patient's skin surface. Staphylococcus aureus a...

Maternal Recto-Vaginal Organisms and Surface Skin Colonization in Infants

Background: Early-onset sepsis is a common cause of neonatal mortality and mainly occurs due to the colonized microorganisms in the maternal recto-vaginal area. The present study aimed to evaluate the effects of maternal risk factors on recto-vaginal colonization and transmission rate of micro-flora from mothers to infants. Methods: Upon admission, two samples were obtained from the distal thi...

Fucosidosis: Deficiency of Alpha-l-fucosidase in Cultured Skin Fibroblasts

Fucosidosis is a newly recognized inborn error of metabolism involving the accumulation o f fucolipids, fucoglycoproteins, a n d fucornucopolysaccharides. T h r e e families h a v e been reported in the literature (1, 2). 1 T h e enzymic defect in fucosidosis has been established b y Van Hoof and Hers (3) as a specific, nearly complete deficiency of the enzyme ~-L-fucosidase. Thusfar, no report...

Early endpoints for acute bacterial skin and skin structure infections.

In this issue of the journal, Friedland et al. (4) present a retrospective analysis of the two CANVAS trials (3), employing the newer endpoints from the U.S. Food and Drug Administration (FDA) (7). First, they are to be congratulated for having the foresight to include sufficient measurements in their trial to allow the reanalysis even prior to the issuance of the new guidelines. The analysis e...

Bacterial Skin Diseases