219. Das Lokalrezidiv nach Radikaloperation colorectaler Carcinome

HIP: Intelligente Suche nach Fachinformationen für das Handwerk

Angesichts des exponentiell wachsenden Informationsangebots im World Wide Web hat sich die Suche nach relevanten Ressourcen und Datenquellen mit der Zeit zu einem eigenständigen Problem entwickelt. Allgemeine Web-Suchmaschinen verwenden für die Erstellung der Rangliste der Treffer Autoritätswerte, die durch Linkanalyseverfahren auf repräsentativen Web-Ausschnitten bestimmt werden (ggf. kombinie...

Lecture Notes for Ph 219 / CS 219 : Quantum Information

Dev126326 219..231

Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyperactivation of Notch in larval neuroblasts leads to tumours, we combined results from profiling the upregulated m...

Dmd067868 209..219

The thiouracil derivative PF-06282999 [2-(6-(5-chloro-2-methoxyphenyl)4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide] is an irreversible inactivator of myeloperoxidase and is currently in clinical trials for the potential treatment of cardiovascular diseases. Concerns over idiosyncratic toxicity arising from bioactivation of the thiouracil motif to reactive species in the liver have bee...

C1lc20678h 219..226

In this work, we developed a microfluidic device for the imitation of drug metabolism in human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three sections: (1) bioreactors containing poly(ethylene) glycol (PEG) hydrogel encapsulated human liver microsomes (HLMs); (2) cell culture chambers for cytotoxicity assay; and (3) integrated micro solid-phase extract...