2113 Corneal transplantation in high-risk patients: Influence of HLA matching

2113 Corneal transplantation in high-risk patients: Influence of HLA matching

To quantify clinical and operative factors influencing comeal graft outcome. MeVlods Multifactorial analysis of 2242 grafts registered by United Kingdom Transplant Service from July 1987 to June 1990. Results Increased risk of graft failure with: pm operative stmmal oedema; small trechine size: difference in donor and recioient sizes areater than 0.25 mm: and mixed ccntinuous and interrupted su...

Non-HLA antigens and HLA-DR matching in corneal transplantation.

The impact of HLA-A matching in corneal transplantation.

Previously, we have reported the results of our retrospective study on the effect of HLA class II allele matching on the outcome of corneal transplant. Here, we demonstrate our findings of the study for HLA class I allele matching in the same study subjects. Eighty transplant recipients were typed for HLA-A, and 79 transplant recipients were typed for HLA-B alleles, by PCR-SSOP. The association...

Influence of HLA-A, HLA-B, and HLA-DR matching on rejection of random corneal grafts using corneal tissue for retrospective DNA HLA typing.

AIM To establish if coincidental HLA-A, HLA-B, and HLA-DR tissue matching is associated with a reduced likelihood of corneal graft rejection. METHODS Organ culture preserved random donor corneas were used for penetrating keratoplasty (PKP). Corneal tissue from all graft recipients and donors or blood samples from recipients after repeated transplantation were obtained in order to perform retr...

HLA matching effect in liver transplantation.

W E HAVE previously shown the HLA matching effect on liver allografts. which suggested the importance of class I matching in liver transplantation. l In this study, using a new set of patients, we reviewed our earlier analysis to study whether or not the class I matching effect still remained. MATERIALS AND METHODS This study consisted of a total of 347 patients who received orthotopic liver tr...