2-Chlorodeoxyadenosine treatment of lymphoid malignancies [editorial]
نویسندگان
چکیده
منابع مشابه
Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA).
We administered one course of 2-chlorodeoxyadenosine (2CdA) at 4 mg/m2 daily for 7 days by continuous intravenous infusion to 46 patients with hairy cell leukemia. Complete remissions occurred in 36 patients (78%; 95% confidence limits, 63% to 89%), partial remissions in five (11%), and a minor response in one. One patient died of candida sepsis 3 weeks after beginning treatment and three patie...
متن کاملModulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies
BACKGROUND The combination of rituximab and 2-CdA is an effective therapy for B-cell tumors. However, the molecular mechanisms and enzymatic pathways involved in the interaction between the two agents are not fully understood. In this study, we provide molecular evidence for positive interaction between these two agents with resultant therapeutic benefit. METHODS Efficacy of the R-2CdA regime...
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Therapy-related acute myeloid leukemia (t-AML) is a heterogeneous entity most frequently related to breast cancer or lymphoproliferative diseases (LD). Population-based studies have reported an increased risk of t-AML after treatment of lymphomas. The aim of this study was to describe the characteristics and outcome of 80 consecutive cases of t-AML following treatment of LD. t-AML accounted for...
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3 4 3 encouraging results, we administered this agent to 10 patients with multiple myeloma staged according to standard criteria6; their clinical features are shown in Table 1. 2CdA was administered at a dose of 0.1 mg/kg/d for 7 days as a continuous infusion via a central venous catheter. Courses were repeated every 4 weeks. One patient received three courses, seven patients received two cours...
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(ARNT; also known as hypoxia inducible factor 1-β) is a member of the basic-helix-loop-helix-Per/ARNT/Sim (bHLH-PAS) family of transcription factors. ARNT is a common binding partner in this family and predominantly heterodimerizes with HIF-1α, or the aryl hydrocarbon receptor (AHR), and aids in the recognition of their respective DNA binding sequences [1]. The AHR has been recognized for decad...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v79.4.843.bloodjournal794843